108619-10-9Relevant academic research and scientific papers
Autoxidation of drugs: Prediction of degradation impurities from results of reaction with radical chain initiators
Boccardi
, p. 431 - 435 (2007/10/02)
In the study of the degradation of drug substances by molecular oxygen, their specific reaction mechanisms must be taken into account. The rate- determining step is usually the reaction of the substrate with a radical chain initiator, which is often an unknown impurity. The reactivity and selectivity of autoxidation can be controlled better by using a radical chain initiator, such as AIBN, than by changing the temperature or the oxygen pressure. In this paper the products profiles of four pharmaceutical substances in a simple oxidation test with AIBN are compared with the results of long term natural stability tests or with already established stabilities.
