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1-[1-(4-Fluorobenzyl)-1H-BenziMidazole-2yl]-N-Methyl-4-piperidineaMine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

108635-83-2

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108635-83-2 Usage

Uses

Mizilastine intermediate

Check Digit Verification of cas no

The CAS Registry Mumber 108635-83-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,6,3 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 108635-83:
(8*1)+(7*0)+(6*8)+(5*6)+(4*3)+(3*5)+(2*8)+(1*3)=132
132 % 10 = 2
So 108635-83-2 is a valid CAS Registry Number.

108635-83-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-{1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl}-N-methyl-4-piperidinamine

1.2 Other means of identification

Product number -
Other names 1-[1-(4-FLUOROBENZYL)-1H-BENZIMIDAZOLE-2YL]-N-METHYL-4-PIPERIDINEAMINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:108635-83-2 SDS

108635-83-2Downstream Products

108635-83-2Relevant academic research and scientific papers

Brain-penetrating 2-aminobenzimidazole H1-antihistamines for the treatment of insomnia

Coon, Timothy,Moree, Wilna J.,Li, Binfeng,Yu, Jinghua,Zamani-Kord, Said,Malany, Siobhan,Santos, Mark A.,Hernandez, Lisa M.,Petroski, Robert E.,Sun, Aixia,Wen, Jenny,Sullivan, Sue,Haelewyn, Jason,Hedrick, Michael,Hoare, Samuel J.,Bradbury, Margaret J.,Crowe, Paul D.,Beaton, Graham

scheme or table, p. 4380 - 4384 (2010/04/05)

The benzimidazole core of the selective non-brain-penetrating H1-antihistamine mizolastine was used to identify a series of brain-penetrating H1-antihistamines for the potential treatment of insomnia. Using cassette PK studies, brain

METHOD AND INTERMEDIA USED TO OBTAIN DERIVATIVES OF 1-(1H- BENZIMIDAZOLE-2-YL)-4-(2-AMINOPYRIMIDINE)PIPERIDINE

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Page 12-13, (2010/02/13)

The invention relates to a method of obtaining derivatives of 1-(1H-benzimidazole-2-il)-4-(2-aminopyrimidine)piperidine (IV), wherein - R1 represents hydrogen or 4-halobenzyl and R5 represents optionally-substituted hydrogen, alkyl or benzyl. The inventive method comprises the conversion of a 1-[1-(R1)-1H-benzimidazole-2-il]-4-(R2)(R3)-piperidine (I), wherein R2 or R3 represents optionally-protected hydroxy, or R2 and R3 represent, independently of each other, optionally-substituted alkoxy or benzyloxy, or R2 and R3 together form an optionally-substituted alkylenedioxy group, by means of hydrolysis and/or oxidation into a 1-[1-(R1)-1H-benzimidazole-2-il]-4-piperidone, which, by reductive amination (with optional separation of the intermediate imina formed) provides the corresponding amine which, by reaction with a pyrimidine, produces the above-mentioned derivative of 1-(1H-benzimidazole-2-il)-4-(2-aminopyrimidine) piperidine (IV).

BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

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, (2008/06/13)

Benzimidazole derivatives corresponding to the formula (1) STR1 in which X is CH or N,R 1 is either a hydrogen atom, or a benzyl radical which can bear 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, (C 1-4)alkyl, (C 1-4)alkoxy, c

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