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1086398-00-6

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1086398-00-6 Usage

General Description

1-BOC-4-(3-FLUOROPHENYL)-PIPERIDINE is a specialized chemical name indicating a distinct compound. From its nomenclature, it can be inferred that this compound features piperidine, a common organic compound used as a building block in the creation of various pharmaceutical drugs. The '1-BOC' indicates a tert-butoxycarbonyl protection group attached to the molecule, which is often used during drug development to temporarily block certain functional groups. The compound also contains a fluorophenyl group, which suggests the presence of a phenyl group (a functional group or local structural fragment related to benzene) in which one hydrogen atom has been replaced by a fluorine atom. Overall, it is likely to be used in research contexts or for drug synthesis. Specific details about its property, use, toxicity, and safety measures would depend on empirical data not included in the chemical name.

Check Digit Verification of cas no

The CAS Registry Mumber 1086398-00-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,6,3,9 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1086398-00:
(9*1)+(8*0)+(7*8)+(6*6)+(5*3)+(4*9)+(3*8)+(2*0)+(1*0)=176
176 % 10 = 6
So 1086398-00-6 is a valid CAS Registry Number.

1086398-00-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-(3-fluorophenyl)piperidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1086398-00-6 SDS

1086398-00-6Downstream Products

1086398-00-6Relevant articles and documents

COMPOUNDS AND USES THEREOF

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Paragraph 1315; 1324, (2019/11/11)

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Design, synthesis and evaluation of substituted piperidine based KCNQ openers as novel antiepileptic agents

Yang, Shaoning,Lu, Dingqiang,Ouyang, Pingkai

, p. 1731 - 1735 (2018/05/04)

Epilepsy is a kind of disease with complicated pathogenesis. KCNQ (Kv7) is a voltage dependent potassium channel that is mostly associated with epilepsy and thus becomes an important target in the treatment of epilepsy. In this paper, a series of substituted piperidine derivatives targeting KCNQ were designed and synthesized by using scaffold hopping and active substructure hybridization. Compounds were evaluated by fluorescence-based thallium influx assay, Rb+ flow assay and electrophysiological patch-clamp assay. Results showed that some compounds possessed more potent potassium channel opening activity than Retigabine. More significantly, compound 11 was found to have good pharmacokinetic profiles in vivo.

Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists

Pasternak, Alexander,Goble, Stephen D.,Vicario, Pasquale P.,Di Salvo, Jerry,Ayala, Julia M.,Struthers, Mary,DeMartino, Julie A.,Mills, Sander G.,Yang, Lihu

, p. 994 - 998 (2008/09/19)

This report describes replacement of the 4-(4-fluorophenyl)piperidine moiety in our CCR2 antagonists with 4-heteroaryl piperidine and 4-(carboxyphenyl)-piperidine subunits. Some of the resulting analogs retained potency in our CCR2 binding assay and had i

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