1086409-78-0

Basic information

• Product Name: N-Amino-11-azaartemisinin
• Synonyms: N-Amino-11-azaartemisinin;(3R,5aS,6R,8aS,9R,12R,12aR)-11-AMinodecahydro-3,6,9-triMethyl-3,12-epoxy-1,2-dioxepino[4,3-i]isoquinolin-10(3H)-one
• CAS NO: 1086409-78-0
• Molecular Formula: C₁₅H₂₄N₂O₄
• Molecular Weight: 296.36206
• Product Categories: Chiral Reagents;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents, Drug Analogues, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1086409-78-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Amino-11-azaartemisinin(CAS DataBase Reference)
• NIST Chemistry Reference: N-Amino-11-azaartemisinin(1086409-78-0)
• EPA Substance Registry System: N-Amino-11-azaartemisinin(1086409-78-0)

Safety Data

• Hazardous Substances Data: 1086409-78-0(Hazardous Substances Data)

Usage

Uses

A derivative of 11-Azaartemisinin which showed a high order of activity against multidrug-resistant malaria by oral route.

Upstream product

• 63968-64-9 C₁₂H₁₃O₂(CH₃)3(O)(OO) 

Downstream Products

• 1086409-91-7 4-(trifluoromethyl)-N-((3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyl-10-oxodecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]-isoquinolin-11(12H)-yl)benzamide 
• 1086409-87-1 N-((3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyl-10-oxodecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-11(12H)-yl)benzamide 
• 1086409-93-9 N-((3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyl-10-oxodecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-11(12H)-yl)-[1,1′-biphenyl]-4-carboxamide 
• 1086409-89-3 4-bromo-N-((3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyl-10-oxodecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-11(12H)-yl)benzamide 
• 1086410-09-4 (3R,5aS,6R,8aS,9R,12R,12aR)-11-(benzylamino)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one 
• 1569269-80-2 (3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyl-11-((4-methylbenzyl)amino)decahydro-3,12-epoxy[1,2]dioxepino[4,3-i]-isoquinolin-10(3H)-one 
• 1569269-81-3 (3R,5aS,6R,8aS,9R,12R,12aR)-11-((4-chlorobenzyl)amino)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one 
• 1569269-82-4 (3R,5aS,6R,8aS,9R,12R,12aR)-11-((4-fluorobenzyl)amino)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one 
• 1086410-14-1 (3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyl-11-((4-(trifluoromethyl)benzyl)amino)decahydro-3,12-epoxy[1,2]-dioxepino[4,3-i]isoquinolin-10(3H)-one 
• 1086410-16-3 (3R,5aS,6R,8aS,9R,12R,12aR)-11-(([1,1′-biphenyl]-4-ylmethyl)amino)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one 
• 1086410-00-5 (3R,5aS,6R,8aS,9R,12R,12aR)-11-(((E)-benzylidene)amino)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isoquinolin-10(3H)-one 
• 1569269-76-6 (3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyl-11-(((E)-4-methylbenzylidene)amino)decahydro-3,12-epoxy[1,2]dioxepino-[4,3-i]isoquinolin-10(3H)-one 
• 1569269-77-7 (3R,5aS,6R,8aS,9R,12R,12aR)-11-(((E)-4-chlorobenzylidene)amino)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]-isoquinolin-10(3H)-one 
• 1569269-78-8 (3R,5aS,6R,8aS,9R,12R,12aR)-11-(((E)-4-fluorobenzylidene)amino)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]-isoquinolin-10(3H)-one 

Relevant articles and documents

11-Aza-artemisinin Derivatives Exhibit Anticancer Activities by Targeting the Fatty Acid Binding Protein 6 (FABP6)

Artemisinin (Qinghaosu), a sesquiterpene lactone isolated from the Chinese medicinal herb Artemisia annua, is famous as the first-line antimalarial drug, and reported to also possess anticancer properties. Though many studies have proceeded focusing on ar

Amino- and hydroxy-functionalized 11-azaartemisinins and their derivatives

(Chemical Equation Presented) An efficient conversion of artemisinin 1 into three new amino- and hydroxy-functionalized 11-aza prototypes 9, 11, and 12 has been achieved on a multigram scale by reaction with hydrazine, hydroxylamine, and 2-amino ethanol, respectively. Of these, 9 has been further diversified into a wide range of derivatives including imines, amines, amides, and linker based dimers. Prototypes 11 and 12 have been converted into the corresponding ethers in high yields. Some of these compounds have shown a high order of activity against multidrug-resistant malaria in mice by oral route.