1086430-07-0Relevant articles and documents
PdCl2-catalyzed cross-coupling reaction of arylacetylene iodides with arylboronic acids to diarylacetylenes
Shi, Yu,Li, Xiaoyu,Liu, Jianhui,Jiang, Wenfeng,Sun, Licheng
, p. 3626 - 3628 (2010)
A new Suzuki-type cross-coupling reaction between 1-iodo-2-arylalkynes and arylboronic acids to afford a wide variety of functionalized diarylacetylenes in a mild reaction condition was developed. The reaction was catalyzed by a small amount of a structurally simple, commercially available, and stable PdCl 2. This unique sp-sp2 carbon-carbon bond formation provides a new protocol for the synthesis of diarylacetylenes, which is a new addition to the Suzuki cross-coupling reaction.
Iodination of terminal alkynes using KI/CuSO4 – A facile method with potential for radio-iodination
Ferris, Trevor,Carroll, Laurence,Mease, Ronnie C.,Spivey, Alan C.,Aboagye, Eric O.
, p. 936 - 939 (2019)
Herein, we report an efficient new method for the iodination of terminal alkynes using stoichiometric KI and CuSO4 in a mix of acetonitrile and acetate buffer that holds promise for further development into a method for radio-iodination.
Halogen-Bonded Supramolecular Capsules in the Solid State, in Solution, and in the Gas Phase
Dumele, Oliver,Schreib, Benedikt,Warzok, Ulrike,Trapp, Nils,Schalley, Christoph A.,Diederich, Fran?ois
, p. 1152 - 1157 (2017)
Supramolecular capsules were assembled by neutral halogen bonding (XB) and studied in the solid state, in solution, and in the gas phase. The geometry of the highly organized capsules is shown by an X-ray crystal structure which features the assembly of t
Acetic Acid Promoted Direct Iodination of Terminal Alkynes with N -Iodosuccinimide: Efficient Preparation of 1-Iodoalkynes
Liu, Liu E.,Xiong, Hangxing,Yang, Sen,Yao, Ming,Zhang, Jingjing
, p. 1102 - 1106 (2020)
An efficient and highly chemoselective approach for the direct iodination of terminal alkynes using acetic acid as N -iodosuccinimide activated reagent under metal-free conditions has been developed. This facile process tolerates a variety of terminal alkynes and provides the desired products in good to excellent yields (up to 99percent).
Efficient synthesis of 1-iodoalkynes: Via Al2O3 mediated reaction of terminal alkynes and N -iodosuccinimide
Yao, Ming,Zhang, Jingjing,Yang, Sen,Xiong, Hangxing,Li, Li,Liu,Shi, Hong
, p. 3946 - 3950 (2020/02/04)
Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al2O3 was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst.
Synthesis, antibacterial and anticancer activity, and docking study of aminoguanidines containing an alkynyl moiety
Deng, Xianqing,Song, Mingxia
, p. 354 - 364 (2020/01/02)
Two series of aminoguanidines containing an alkynyl moiety were designed, synthesised, and screened for antibacterial and anticancer activities. Generally, the series 3a–3j with a 1,2-diphenylethyne exhibited better antibacterial activity than the other series (6a–6k) holding 1,4-diphenylbuta-1,3-diyne moiety antibacterial activity. Most compounds in series 3a–3j showed potent growth inhibition against the tested bacterial strains, with minimum inhibitory concentration (MIC) values in the range 0.25–8 μg/mL. Compound 3g demonstrated rapid and persistent bactericidal activity at 2 × MIC. The resistance study revealed that resistance of the tested bacteria towards 3g is not easily developed. Molecular docking studies revealed that compounds 3g and 6e bind strongly to the LpxC and FabH enzymes. Moreover, excellent activity of selected compounds against the growth of cancer cell lines A549 and SGC7901 was also observed, with IC50 values in the range 0.30–4.57 μg/mL. These findings indicate that compounds containing the aminoguanidine moiety are promising candidates for the development of new antibacterial and anticancer agents.
Protection/deprotection-free syntheses and structural analysis of (keto-aryl)diynes
Osowska, Karolina,Lis, Tadeusz,Szafert, Slawomir
experimental part, p. 4598 - 4606 (2009/05/11)
The reactions of precursors 4-BrC6H4COR with TMSC≡CH (Sonogashira coupling) followed by in situ deprotection and subsequent dimerization gave thermally stable dimeric ketodiynes RCOC 6H4(C≡C)2C6
