1086462-77-2Relevant academic research and scientific papers
Solid-phase synthesis of 5-arylhistidines via a microwave-assisted Suzuki-Miyaura cross-coupling
Cerezo, Vanessa,Amblard, Muriel,Martinez, Jean,Verdié, Pascal,Planas, Marta,Feliu, Lidia
, p. 10538 - 10545 (2008/12/22)
Microwave irradiation efficiently promoted the solid-phase Suzuki-Miyaura reaction of a 5-bromohistidine with various arylboronic acids in the presence of a palladium catalyst. This methodology allowed the synthesis of peptides bearing a histidine residue substituted at position 5 of the imidazole ring with a phenyl, a substituted phenyl, a pyridyl, or a thienyl ring, as well as with the benzene ring of a tyrosine residue.
