108649-45-2

Upstream product

• 610-99-1 1-(2-Hydroxy-phenyl)-propan-1-on 
• 3005-50-3 N,N'-Thionyldiimidazole 

Downstream Products

• 108648-68-6 1-<1-<4-<(chlorobenzyl)oxy>phenyl>-2-methylvinyl>-1H-imidazole 
• 108648-86-8 1-((E)-1-{2-[1-(3-Chloro-phenyl)-ethoxy]-phenyl}-propenyl)-1H-imidazole 
• 85127-76-0 1-tert-Butylamino-3-[2-((E)-1-imidazol-1-yl-propenyl)-phenoxy]-propan-2-ol 
• 85127-75-9 1-[2-((E)-1-Imidazol-1-yl-propenyl)-phenoxy]-3-isopropylamino-propan-2-ol 

Relevant academic research and scientific papers

Synthesis and Antifungal Activity of New 1-Vinylimidazoles

Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III.Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imi

Synthesis and antiarrhythmic activity of new 1-[1-[2-[3-(alkylamino)-2-hydroxypropoxy]phenyl]vinyl]-1H-imidazoles and related compounds

Various 1-[1-[2-[3-(alkylamino)-2-hydroxypropoxy]phenyl]vinyl]-1H-azoles were synthesized and investigated for β-adrenoceptor-blocking and antiarrhythmic activities. Although no compounds showed more potent β-blocking effects than propranolol in the isolated guinea pig right atria, many compounds exhibited significant antiarrhythmic effects against aconitine or ischemic arrhythmia in mice or dogs. 1-[2,5-Dichloro-6-[1-(1H-imidazol-1-yl)ethenyl]phenoxy]-3-[(1-methylethyl) amino]-2-propanol hydrochloride (48) (711389-S) was selected as a candidate for clinical evaluation in man, since its antiarrhythmic effects were superior to those of quinidine, disopyramide, or propranolol. Asymmetric synthesis of (R)-(+)- and (S)-(-)-48 is described, and it is proven that there is no stereospecificity in the antiarrhythmic effect of 48.