108656-18-4Relevant academic research and scientific papers
A step-economical route to fused 1,2,3-triazoles via an intramolecular 1,3-dipolar cycloaddition between a nitrile and an in situ generated aryldiazomethane
Mani, Neelakandha S.,Fitzgerald, Anne E.
, p. 8889 - 8894 (2015/01/08)
An intramolecular 1,3-dipolar cycloaddition strategy for rapid entry into triazole-fused heterocyclic compounds without recourse to the traditional Cu(1)-catalyzed azide-alkyne cycloadditions is described. Central to the strategy is the in situ generation of substituted diazomethanes in a two-step sequence from the corresponding aldehydes, which then undergo smooth cycloaddition with a cyano group to generate the desired fused 1,2,3-triazoles in good overall yields. The entire sequence can be carried out in a onepot operation.
A Novel Synthesis of Benzofuran and Related Compounds. I. The Vilsmeier Reaction of Phenoxyacetonitriles
Hirota, Takashi,Fujita, Hiroko,Sasaki, Kenji,Namba, Tetsuto,Hayakawa, Shohei
, p. 1347 - 1351 (2007/10/02)
A novel synthesis of 2-benzofurancarboxylic acid derivatives by the Vilsmeier reaction of phenoxyacetonitriles is described.
