1086600-36-3

Basic information

• Product Name: tert-butyl 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenethylcarbaMate
• Synonyms: tert-Butyl N-{2-[2-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}carbamate
• CAS NO: 1086600-36-3
• Molecular Formula: C₁₉H₃₀BNO₄
• Molecular Weight: 347.2568
• Mol File: 1086600-36-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenethylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenethylcarbaMate(1086600-36-3)
• EPA Substance Registry System: tert-butyl 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenethylcarbaMate(1086600-36-3)

Safety Data

• Hazardous Substances Data: 1086600-36-3(Hazardous Substances Data)

Upstream product

• 65185-58-2 2-(2-bromophenyl)ethanamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 73183-34-3 bis(pinacol)diborane 
• 171663-06-2 N-(tert-butoxycarbonyl)-2-(2-bromophenyl)-ethylamine 

Downstream Products

• 1086601-80-0 [2-(2-{2-[5-fluoro-2-(2-[1,2,3]triazol-1-yl-ethylamino)-pyrimidin-4-yl]-benzo[b]thiophen-7-yl}-phenyl)-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

2-METHYL-QUINAZOLINES

The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions. The 2-methyl substituted quinazoline compounds of general formula(I) effectively and selectively inhibit the Ras-Sos interaction without significantly targeting the EGFR receptor. They are therefore useful for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, such as cancer as a sole agent or in combination with other active ingredients.