1086639-59-9

Basic information

• Product Name: Y 11
• Synonyms: Y 11;3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-(2-hydroxyethyl)-, broMide;1-(2-Hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane BroMide;NSC206142
• CAS NO: 1086639-59-9
• Molecular Formula: C8H17BrN4O
• Molecular Weight: 265.15078
• Mol File: 1086639-59-9.mol
• Article Data: 0

Chemical Properties

• Appearance: white to beige/
• Storage Temp.: ?20°C
• Solubility: H2O: soluble25mg/mL, clear
• CAS DataBase Reference: Y 11(CAS DataBase Reference)
• NIST Chemistry Reference: Y 11(1086639-59-9)
• EPA Substance Registry System: Y 11(1086639-59-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 1086639-59-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1086639-59-9 differently. You can refer to the following data:
1. Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are over-expressed in many types of cancer. Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397. At 100 μM, it was shown to decrease cell viability of T47D breast cancer and C8161 melanoma cell lines.[Cayman Chemical]
2. Y 11 is a potent inhibitor of focal adhesion kinase (FAK); Y 11 prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Y 11 decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.