108664-54-6

Basic information

• Product Name: 3-[2-(4-chlorophenyl)-1-(hydroxymethyl)-2-oxoethyl]quinazolin-4(3H)-one
• Synonyms: 3-[1-(4-chlorophenyl)-3-hydroxy-1-oxopropan-2-yl]quinazolin-4(3H)-one; 3-Hydroxy-2-(4-oxo-3,4-dihydroquinazolin-3-yl)-4'-chloropropiophenone; 4(3H)-quinazolinone, 3-[2-(4-chlorophenyl)-1-(hydroxymethyl)-2-oxoethyl]-
• CAS NO: 108664-54-6
• Molecular Formula: C₁₇H₁₃ClN₂O₃
• Molecular Weight: 328.7497
• Mol File: 108664-54-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 570.7°C at 760 mmHg
• Flash Point: 298.9°C
• Density: 1.38g/cm³
• Vapor Pressure: 7.29E-14mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: 3-[2-(4-chlorophenyl)-1-(hydroxymethyl)-2-oxoethyl]quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(4-chlorophenyl)-1-(hydroxymethyl)-2-oxoethyl]quinazolin-4(3H)-one(108664-54-6)
• EPA Substance Registry System: 3-[2-(4-chlorophenyl)-1-(hydroxymethyl)-2-oxoethyl]quinazolin-4(3H)-one(108664-54-6)

Safety Data

• Hazardous Substances Data: 108664-54-6(Hazardous Substances Data)

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 491-36-1 4-Hydroxyquinazoline 
• 50-00-0 formaldehyd 
• 90059-70-4 2-(4-oxo-3,4-dihydroquinazolin-3-yl)-4'-chloropropiophenone 

Relevant articles and documents

Synthesis and Antifungal Activity of a Series of Novel 1,2-Disubstituted Propenones

To find an antifungal agent other than those of the imidazole and triazole series, a new class of 1,2-disubstituted propenones I and II was prepared and tested for antifungal activity.Comparison of the structure-activity relationships showed that the conjugated structure of carbonyl and exomethylene groups in I and II plays an important role in potent antifungal acivity.However, it is noteworthy that compounds 53, 54, and 56, which have a hydroxymethyl or methoxymethyl group instead of an exo-methylene group in I, also showed potent activity.Although many compounds exhibited strong antifungal activity in vitro, none showed activity in vivo of oral efficacy against subacute systemic candidiasis in mice. '