108664-81-9Relevant academic research and scientific papers
Copper-catalyzed three-component: N -alkylation of quinazolinones and azoles
Deng, Guo-Jun,Huang, Huawen,Ji, Xiaochen,Wang, Chunlian
supporting information, p. 1200 - 1204 (2022/02/21)
A Cu-catalyzed three-component N-alkylation coupling reaction of N-heteroarenes with methyl ketones and DMPA as a carbon source has been developed. Using methyl ketones as alkylation reagents and DMPA (N,N′-dimethylpropionamide) as a carbon source, the re
SYNTHESIS AND ANALGETIC EFFICIENCY OF SOME OXY AND OXO DERIVATIVES OF 4(3H)-QUINAZOLINONE
Fisnerova, Ludmila,Brunova, Bohumila,Kocfeldova, Zuzana,Tikalova, Jana,Maturova, Eva,Grimova, Jaroslava
, p. 2373 - 2381 (2007/10/02)
A series of 3-substituted 4(3H)-quinazolinone derivatives have been prepared by alkylation of 4(3H)-quinazolinone with halogenoethers, halogenoketones, and Mannich bases, and the products have been tested for analgetic effects.The most interesting represe
Synthesis and Antifungal Activity of a Series of Novel 1,2-Disubstituted Propenones
Ogata, Masaru,Matsumoto, Hiroshi,Kida, Shiro,Shimizu, Sumio,Tawara, Katsuya,Kawamura, Yoshimi
, p. 1497 - 1502 (2007/10/02)
To find an antifungal agent other than those of the imidazole and triazole series, a new class of 1,2-disubstituted propenones I and II was prepared and tested for antifungal activity.Comparison of the structure-activity relationships showed that the conjugated structure of carbonyl and exomethylene groups in I and II plays an important role in potent antifungal acivity.However, it is noteworthy that compounds 53, 54, and 56, which have a hydroxymethyl or methoxymethyl group instead of an exo-methylene group in I, also showed potent activity.Although many compounds exhibited strong antifungal activity in vitro, none showed activity in vivo of oral efficacy against subacute systemic candidiasis in mice. '
