1086820-95-2Relevant academic research and scientific papers
Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents
Penthala, Narsimha Reddy,Sonar, Vijayakumar N.,Horn, Jamie,Leggas, Markos,Yadlapalli, Jai Shankar K. B.,Crooks, Peter A.
, p. 1073 - 1078 (2013)
A new library of small molecules with structural features resembling combretastatin analogs was synthesized and evaluated for anticancer activity against a panel of 60 human cancer cell lines. Three novel acrylonitrile analogs (5, 6 and 13) caused a signi
COMBRETASTATIN ANALOGS
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Paragraph 0149, (2014/11/11)
The present invention relates novel heterocyclic analogs of combretastatin, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I), Formula (II), and Formula (V) are provided.
(E)-3-(Benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (Z)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile
Sonar, Vijayakumar N.,Parkin, Sean,Crooks, Peter A.
, p. o743-o745 (2008/09/18)
The title compounds, C20H17NO3S, (I), and C19H15NO2S, (II), were prepared by the reaction of benzo[b]thio-phene-2-carbaldehyde with (3,4,5-trimethoxy- phenyl)-acetonitrile and (3,4-dimethoxy-phenyl)-acetonitrile, respectively, in the presence of methanoli
