108694-64-0Relevant academic research and scientific papers
Convergence with Mutual Kinetic Resolution. 1. Studies Defining Methodology for the Taxol C/D Ring Fragment and Synthezis of the A Ring Fragment
Lin, James,Nikaido, Madelene M.,Clark, Glenn
, p. 3745 - 3752 (1987)
4-Exo-tet cyclization gives the alkoxyoxethane of the taxol C/D ring fragment if the tertiary alcohol is protected.Cycloaddition of dichloroketene and 1--2-methylcyclohex-2-ene, a model for the allylic ether 6, succeeds in the presence of DME.The synthesis of the A ring fragment relies on the Diels-Alder reaction of 1-ethoxy-3--2-methyl-1,3-butadiene with ethyl (E)-2-acetoxyacrylate and the axial conjugate addition of a vinyl Normant reagent.
