108713-03-7

Basic information

• Product Name: (S)-2-Methyl-butyric acid (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester
• Synonyms: (S)-2-Methyl-butyric acid (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester
• CAS NO: 108713-03-7
• Molecular Weight: 628.924
• Mol File: 108713-03-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-Methyl-butyric acid (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Methyl-butyric acid (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester(108713-03-7)
• EPA Substance Registry System: (S)-2-Methyl-butyric acid (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester(108713-03-7)

Safety Data

• Hazardous Substances Data: 108713-03-7(Hazardous Substances Data)

Upstream product

• 108712-60-3 <4S-<4α,5α(2S^*,4S^*,6S^*),5aα,6β,8aα,8bα>>-6-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-5-<2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>tetrahydro-6-methoxy-2H-pyran-2-yl>ethyl>-4,5,5a,6,7,8,8a,8b-octahydro-4-methyl-3H-naphth<1,8-cd>isoxazole 
• 108712-61-4 (3S,4S,4aR,5S,8R,8aR)-5-(tert-Butyl-dimethyl-silanyloxy)-4-{2-[(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-8-hydroxy-3-methyl-octahydro-naphthalen-1-one 
• 108712-59-0 (3S,4S)-4-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-6-[(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-3-methyl-hexanal oxime 
• 108712-62-5 <3S-<3α,4α(2S^*,4S^*,6S^*),4aα,5β>>-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-<2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>tetrahydro-6-methoxy-2H-pyran-2-yl>ethyl>-3,4,4,a,5,6,7,-hexahydro-3-methyl-1(2H)-naphthalenone 
• 108712-63-6 (1S,3S,4S,4aR,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-{2-[(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-3-methyl-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-ol 
• 108712-64-7 <1S-<1α(2S^*,4S^*,6S^*),2α,8β,8aα>>-(1,1-dimethylethyl)-<<2-<2-<8-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1,2,6,7,8,8a-hexahydro-2-methyl-1-naphthalenyl>ethyl>tetrahydro-6-methoxy-2H-pyran-4-yl>oxy>diphenylsilane 
• 108712-66-9 (S)-2-Methyl-butyric acid (1S,7S,8S,8aR)-8-{2-[(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester 
• 108712-65-8 (1S,7S,8S,8aR)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-ol 
• 1730-91-2 (S)-2-Methylbutyric acid 
• 108743-01-7 (S)-2-Methyl-butyric acid (1S,7S,8S,8aR)-8-{2-[(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester 

Downstream Products

• 73573-88-3 mevastatin 

Relevant articles and documents

The Isoxazoline Route to the Hypocholesterolemic Agent Compactin: Use of the Isoxazoline as a 1,3-Diene Equivalent

A total synthesis of the hypocholesterolemic agent compactin is described in which the hexahydronaphthalene portion of this molecule is constructed by an intramolecular nitrile oxide cycloaddition reaction.In the context of this synthesis, the isoxazoline ring system was found to serve as a useful 1,3-diene equivalent.The protocol developed for this conversion involves transformation of the isoxazoline to an allylic alcohol followed by regioselective dehydration using aluminum oxide.Molecular mechanics calculations on compactin-related octahydronaphthisoxazoles are also presented.