1087161-01-0Relevant academic research and scientific papers
Synthesis of diverse 6-(1,2-disubstituted ethyl)purine bases and nucleosides via 6-(oxiran-2-yl)purines
Kucha?, Martin,Pohl, Radek,Klepetá?ová, Blanka,Hocek, Michal
, p. 10355 - 10364 (2008/12/23)
Dihydroxylation of 6-vinylpurines with t-BuOOH and OsO4 gave 6-(1,2-dihydroxyethyl)purines 2, while the epoxidation with H2WO4 and t-BuOOH afforded 6-(oxiran-2-yl)purines 3. Oxirane ring-opening reactions of 3 with diverse nucleophiles gave a series of title 6-(1,2-disubstituted ethyl)purine bases and nucleosides, which were tested for cytostatic and antiviral activities.
