108717-99-3Relevant academic research and scientific papers
Direct: Para -C-H heteroarylation of anilines with quinoxalinones by metal-free cross-dehydrogenative coupling under an aerobic atmosphere
Xu, Jun,Huang, Lin,He, Lei,Liang, Chenfeng,Ouyang, Yani,Shen, Jiabin,Jiang, Min,Li, Wanmei
, p. 6632 - 6638 (2021)
Herein, a green and efficient metal-free cross-dehydrogenative coupling (CDC) for the direct para-C-H heteroarylation of anilines with quinoxalinones has been described. This reaction is performed in H2O/DMSO (v/v = 2?:?1) using air as the sole oxidant. Various anilines (primary, secondary and tertiary amines) and quinoxalinones are well compatible, affording the corresponding products in moderate-to-good yields. Such a methodology provides an environmentally friendly and efficient alternative for the late-stage modification of nitrogen-containing compounds.
