1087197-79-2Relevant academic research and scientific papers
Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists
Trani, Giancarlo,Baddeley, Stuart M.,Briggs, Michael A.,Chuang, Tsu T.,Deeks, Nigel J.,Johnson, Christopher N.,Khazragi, Abir A.,Mead, Tania L.,Medhurst, Andrew D.,Milner, Peter H.,Quinn, Leann P.,Ray, Alison M.,Rivers, Dean A.,Stean, Tania O.,Stemp, Geoffrey,Trail, Brenda K.,Witty, David R.
scheme or table, p. 5698 - 5700 (2009/06/18)
Starting from a benzazepine sulfonamide 5-HT6 receptor antagonist lead with limited brain penetration, application of a strategy of conformational constraint and reduction of hydrogen bond donor count led to a novel series of tricyclic derivati
