108723-79-1Relevant academic research and scientific papers
Oligopyridine ligands derived from amino acid precursors: Their Zn 2+ complexation and effects on hepatic stellate cell functions
Tsukube, Hiroshi,Noda, Yuki,Kataoka, Yumiko,Miyake, Hiroyuki,Shinoda, Satoshi,Kojima-Yuasa, Akiko,Nishida, Yoshitake,Matsui-Yuasa, Isao
, p. 4038 - 4043 (2008)
A series of oligopyridine ligands were derived from amino acid amides in which amide oxygen and ternary nitrogen atoms were combined with pyridine moieties. 1H NMR and circular dichroism spectroscopic characterizations revealed that they formed stable Zn2+ complexes in neutral aqueous solutions and caused Zn2+ deficiency in the hepatic stellate cell systems. Since collagen synthesis was effectively promoted in the cells, the present oligopyridine derivatives worked as biocompatible ligands for Zn2+ complexation and cell activation.
ADENOSINE RECEPTOR BINDING COMPOUNDS
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Paragraph 00296, (2020/02/06)
The present invention relates to pharmaceutical compounds and compositions of Formula (I) and methods of treatment using the compounds and compositions, especially for the treatment and/or prevention of a proliferation disorder, such as cancer. Compounds of Formula (I) as further described herein are shown modulators of the adenosine A2A receptor and exhibit antiproliferative activity. Accordingly, these compounds are useful to treat proliferative disorders such as cancer, and other adenosine receptor-related conditions including an inflammatory disease, renal disease, diabetes, vascular disease, lung disease, or an autoimmune disease.
