1087243-32-0Relevant academic research and scientific papers
Discovery and synthesis of 2-amino-1-methyl-1H-imidazol-4(5H)-ones as GPCR ligands; an approach to develop breast cancer drugs via GPCR associated PAR1 and PI3Kinase inhibition mechanism
Ashok,Shivananda,Manikandan,Chandrasekaran
, p. 641 - 651 (2019)
Efforts were taken to synthesis and characterize 2-amino-1-methyl-1H-imidazole-4(5H)-one derivatives (4a-u) through a four-step reaction. The achieved compounds in remarkable yield have characterized through standard analytical techniques such as FTIR, LC
Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors
Ghosh, Arun K.,Gong, Gangli,Grum-Tokars, Valerie,Mulhearn, Debbie C.,Baker, Susan C.,Coughlin, Melissa,Prabhakar, Bellur S.,Sleeman, Katrina,Johnson, Michael E.,Mesecar, Andrew D.
scheme or table, p. 5684 - 5688 (2009/05/30)
Design, synthesis and biological evaluation of a series of 5-chloropyridine ester-derived severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors is described. Position of the carboxylate functionality is critical to potency. I
