1087347-38-3

Upstream product

• 877995-77-2 1-(4-bromophenoxy)-2-(2,6-dichloro-4-methylphenoxy)ethane 
• 1026786-84-4 3-hydroxy-5-[(1E)-3-(methyloxy)-1-propen-1-yl]benzaldehyde 
• 1026786-87-7 3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde 
• 1026786-89-9 [(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{(1E)-3-methoxyprop-1-en-1-yl}benzyl)amino]cyclopropane 
• 921630-48-0 [(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane 
• 930798-40-6 (4-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]phenyl)-boronic acid 
• 946003-24-3 (3R,4S)-4-{4-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 
• 106-41-2 4-bromo-phenol 
• 1026786-65-1 1-tert-butyl 3-ethyl (3R,4S)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate 
• 1026786-61-7 1-(tert-butyl) 3-ethyl 4-{4-[2-(2.6-dichloro-4-methylphenoxy)ethoxy]phenyl}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate 
• 1026787-15-4 tert-butyl (3R,4S)-3-({[3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-(3-methoxypropyl)benzyl](cyclopropyl)amino}carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate 
• 1026786-63-9 1-(tert-butyl) 3-ethyl 4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1,3-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 626-41-5 3,5-dibromophenol 

Relevant academic research and scientific papers

NOVEL CASE OF RENIN INHIBITORS

The present invention relates to piperidine-based renin inhibitor compounds having carboxylate or carboxylic acid terminal groups. The disclosed low molecular weight, orally active renin inhibitors are of non-peptide nature and have long duration of action. The compounds can be used in the treatment of cardiovascular events and renal insufficiency.