1087347-40-7

Upstream product

• 176525-98-7 1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate 
• 55162-34-0 1-bromo-4-(2-chloroethoxy)benzene 
• 98977-34-5 1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate 
• 4644-61-5 ethyl 4-piperidone-3-carboxylate hydrochloride 
• 626-41-5 3,5-dibromophenol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1026786-63-9 1-(tert-butyl) 3-ethyl 4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1,3-dicarboxylate 
• 1026787-15-4 tert-butyl (3R,4S)-3-({[3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-(3-methoxypropyl)benzyl](cyclopropyl)amino}carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate 
• 1026787-16-5 tert-butyl (3R,4S)-3-{[[3-hydroxy-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate 
• 1026786-61-7 1-(tert-butyl) 3-ethyl 4-{4-[2-(2.6-dichloro-4-methylphenoxy)ethoxy]phenyl}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate 
• 1026786-65-1 1-tert-butyl 3-ethyl (3R,4S)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate 
• 106-41-2 4-bromo-phenol 
• 946003-24-3 (3R,4S)-4-{4-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-phenyl}-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 
• 930798-40-6 (4-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]phenyl)-boronic acid 

Relevant academic research and scientific papers

NOVEL CASE OF RENIN INHIBITORS

The present invention relates to piperidine-based renin inhibitor compounds having carboxylate or carboxylic acid terminal groups. The disclosed low molecular weight, orally active renin inhibitors are of non-peptide nature and have long duration of action. The compounds can be used in the treatment of cardiovascular events and renal insufficiency.