108743-20-0 Usage
General Description
(N-(4-amino-4-deoxy-N(10)-methylpteroyl)amino)-3-chloro-4,5-dihydro-5-isoxazoleacetic acid is a chemical compound that belongs to the pteroylpolyglutamate class of compounds. It is a folic acid derivative and is commonly used in the treatment of folic acid deficiency and anemia. (N-(4-amino-4-deoxy-N(10)-methylpteroyl)amino)-3-chloro-4,5-dihydro-5-isoxazoleacetic acid is a synthetic form of folic acid and is often used as a supplement in food and pharmaceuticals. It plays a crucial role in the synthesis of DNA and RNA, as well as in the production of red blood cells. Additionally, it is also used in the treatment of certain types of cancer, where it helps in the growth and repair of normal cells and tissues.
Check Digit Verification of cas no
The CAS Registry Mumber 108743-20-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,7,4 and 3 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 108743-20:
(8*1)+(7*0)+(6*8)+(5*7)+(4*4)+(3*3)+(2*2)+(1*0)=120
120 % 10 = 0
So 108743-20-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H20ClN9O4/c1-30(8-10-7-24-17-15(25-10)16(22)27-20(23)28-17)11-4-2-9(3-5-11)18(31)26-14(19(32)33)12-6-13(21)29-34-12/h2-5,7,12,14H,6,8H2,1H3,(H,26,31)(H,32,33)(H4,22,23,24,27,28)/t12-,14-/m0/s1
108743-20-0Relevant articles and documents
Methotrexate Analogues. 30. Dihydrofolate Reductase Inhibition and in Vitro Tumor Cell Growth Inhibition by Nε-(Haloacetyl)-L-lysine and Nδ-(Haloacetyl)-L-ornithine Analogues and an Acivicin Analogue of Methotrexate
Rosowsky, Andre,Solan, Vishnu C.,Forsch, Ronald A.,Delcamp, Tavner J.,Baccanari, David P.,Freisheim, James H.
, p. 1463 - 1469 (2007/10/02)
Analogues of methotrexate (MTX) with strong alkylating activity were prepared by replacing the L-glutamate side chain with Nω-haloacetyl derivatives of L-lysine and L-ornithine.Haloacetylation was accomplished in 30-40percent yield by reaction
