1087644-25-4

Basic information

• Product Name: N-(4-Piperidin-1-yl-1,3,5-triazin-2-yl)benzamide
• Synonyms: N-(4-Piperidin-1-yl-1,3,5-triazin-2-yl)benzamide
• CAS NO: 1087644-25-4
• Molecular Formula: C15H17N5O
• Molecular Weight: 283.32838
• Mol File: 1087644-25-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-Piperidin-1-yl-1,3,5-triazin-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Piperidin-1-yl-1,3,5-triazin-2-yl)benzamide(1087644-25-4)
• EPA Substance Registry System: N-(4-Piperidin-1-yl-1,3,5-triazin-2-yl)benzamide(1087644-25-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1087644-25-4(Hazardous Substances Data)

Upstream product

• 32330-92-0 4-piperidin-1-yl-[1,3,5]triazin-2-ylamine 
• 140-29-4 phenylacetonitrile 

Relevant articles and documents

Copper-Catalyzed Tandem Reactions of 2-Amine-[1,3,5]triazines with Nitriles

Copper-catalyzed intermolecular annulation of 2-amine-[1,3,5]triazines and aryl nitriles for the synthesis of [1,2,4]triazolo[1,5-a][1,3,5]triazines via N-C bond formation and oxidative N-N coupling [oxidative 3 + 2 cyclization] is presented. A wide range of aryl nitriles, including electron-rich benzonitriles, electron-poor benzonitriles, 2-cyanothiophene, and 4-cyanopyridine, were all functionalized with 2-amine-[1,3,5]triazines. Furthermore, amidation of 2-amine-[1,3,5]triazines via Cu-catalyzed C-CN bond cleavage of phenylacetonitriles is also demonstrated. The reaction occurred in moderate to satisfactory yields and tolerated alkyl- or aryl-substituted 2-amine-[1,3,5]triazines. Aniline, aminopyridine, and aminopyrimidine also afforded the desired products.