108783-91-1

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 4-(4-ETHOXYPHENYL)-2,4-DIOXOBUTANOATE is used as a building block or intermediate for the synthesis of pharmaceutical compounds due to its potential biological activities.
Used in Organic Synthesis:
METHYL 4-(4-ETHOXYPHENYL)-2,4-DIOXOBUTANOATE is used as a chemical intermediate in the synthesis of various organic compounds, contributing to the development of new chemical entities with potential applications in different fields.

InChI:InChI=1/C13H14O5/c1-3-18-10-6-4-9(5-7-10)11(14)8-12(15)13(16)17-2/h4-8,14H,3H2,1-2H3/b11-8-

Upstream product

• 553-90-2 Dimethyl oxalate 
• 1676-63-7 4'-ethoxyacetophenone 

Downstream Products

• 887250-19-3 (Z)-3-(4-ethoxyphenacylidene)-1-phenyl-1,2,3,4-tetrahydroquinoxalin-2-one 
• 1289383-43-2 3-(4-ethoxybenzoyl)pyrrolo[1,2-a]quinoxaline-1,2,4(5H)-trione 
• 1289383-55-6 3-(4-ethoxybenzoyl)furo[3,2-b]quinoxalin-2(4H)-one 
• 1289383-32-9 (Z)-3-[2-oxo-2-(4-ethoxyphenyl)ethylidene]-3,4-dihydroquinoxalin-2(1H)-one 

Relevant academic research and scientific papers

Bcl-2/MDM2 Dual Inhibitors Based on Universal Pyramid-Like α-Helical Mimetics

No α-helical mimetic that exhibits Bcl-2/MDM2 dual inhibition has been rationally designed due to the different helicities of the α-helixes at their binding interfaces. Herein, we extracted a one-turn α-helix-mimicking ortho-triarene unit from o-phenylene foldamers. Linking benzamide substrates with a rotatable C-N bond, we constructed a novel semirigid pyramid-like scaffold that could support its two-turn α-helix mimicry without aromatic stacking interactions and could adopt the different dihedral angles of the key residues of p53 and BH3-only peptides. On the basis of this universal scaffold, a series of substituent groups were installed to capture the key residues of both p53TAD and BimBH3 and balance the differences of the bulks between them. Identified by FP, ITC, and NMR spectroscopy, a compound 6e (zq-1) that directly binds to Mcl-1, Bcl-2, and MDM2 with balanced submicromolar affinities was obtained. Cell-based experiments demonstrated its antitumor ability through Bcl-2/MDM2 dual inhibition simultaneously.

A class of 1, 5 - diphenyl pyrazole - 3 - carboxylic acid compound and use thereof

The invention provides a 1, 5-diphenyl pyrazol-3-carboxylic acid compound and application thereof. The compound has a structure as shown in general formula I, wherein R1 is selected from -H, halogen, saturated alkyl of C1-C6, or -X1-R4; R2 is selected from H, halogen, saturated alkyl of C1-C6, or -X2-R5; R3 is selected from H, -NH2 or -NH-CO-Ph-(o, m, p)R6; R6 is selected from H, halogen, saturated alkyl of C1-C6, or -O-R7; X1 and X2 are respectively selected from O or S independently; R4, R5 and R7 are respectively selected from H, saturated alkyl of C1-C6, benzyl or phenyl substituted by saturated alkyl of C1-C6 independently. The compound provided by the invention simulates BH3-only and p53TAD protein alpha-helix at the same time, competitively binds and antagonize Mcl-1, Bcl-2 and MDM2 protein, and specifically causes tumor cell apoptosis, thereby realizing application as an anticancer compound. (general formula I).