108784-59-4

Upstream product

• 96694-00-7 1-methyl-3-trimethylsilylindole 
• 930-68-7 cyclohexenone 
• 603-76-9 1-methylindole 
• 108802-15-9 1-(1-methyl-3-indolyl)-3-trimethylsiloxy-cyclohexene 

Relevant academic research and scientific papers

Solid acid-catalysed michael-type conjugate addition of indoles to electron-poor C=C bonds: Towards high atom economical semicontinuous processes

In this paper a novel application of solid acid catalysts in the chemoselective Friedel-Crafts (FC) alkylation of indoles is reported. The optimal protocol allows highly functionalised indolyl compounds to be synthesised in excellent yields through conjug

A rapid and highly efficient Michael addition of methoxybenzenes and indoles to α,β-unsaturated ketones using BF3·OEt2 as a catalyst

An efficient and general protocol is described for the Michael addition of α,β-unsaturated ketones with electron-rich arenes/indoles to give alkylated arenes/indoles under mild reaction condition at room temperature. Shorter reaction time, convenient and

Sulfonic acid-functionalized magnetic nanoparticles as a recyclable and eco-friendly catalyst for atom economical Michael addition reactions and bis indolyl methane synthesis

A modified sulfonic acid functionalized magnetic nanoparticle composite (Fe3O4@γFe2O3-SO3H) is prepared by the use of ultrasonic irradiation. By this modification, the size of the nano-particles was r

Ruthenium-catalyzed direct C3 alkylation of indoles with α,β-unsaturated ketones

In this paper, a simple and highly efficient ruthenium-catalyzed direct C3 alkylation of indoles with various α,β-unsaturated ketones without chelation assistance has been developed. This novel C-H activation methodology exhibits a broad substrate scope s

Highly effective and regioselective Michael addition of indoles to α,β-unsaturated ketones promoted by pentafluorophenylammonium triflate

A simple, inexpensive, environmentally friendly and efficient route for Michael addition of indoles to α,β-unsaturated ketones using pentafluorophenylammonium triflate (PFPAT) as a catalyst is described. Various indole derivatives were synthesized in good

Bismuth nitrate-catalyzed michael reactions of indoles in water

A remarkable and simple bismuth nitrate-catalyzed Michael reaction of indoles with 1,2-unsaturated ketones in water has been developed to reduce the complications that characterize the current standard conditions.

Hafnium trifluoromethanesulfonate [Hf(OTf)4]-catalyzed conjugate addition of indoles to α,β-enones

Hafnium trifluoromethanesulfonate [Hf(OTf)4]- and scandium trifluoromethanesulfonate [Sc(OTf)3]-catalyzed conjugated addition of 3-position of indoles to several enones proceeded in acetonitrile as solvent. Especially, Hf(OTf)4

The ultra high pressure conjugate addition of indoles to electron- deficient olefins

The addition of indole and methyl indole at both high and ambient pressures to a series of Michael acceptors under the influence of ytterbium triflate was investigated. Under ambient pressure the more reactive and less sterically hindered electrophiles ga

An New Method for the Synthesis of 3-Substituted Indoles by ipso-Substitution

Acylation of 3-(trimethylsilyl)-indole 1a with acylhalides 2 affords 3-acylindoles 4. 3-(Trimethylsilyl)-indoles 1a, b react with Michael-acceptors 5 and 8 in presence of Lewis acids to yield the 3-substituted indoles 6, 9, and 10.