108797-27-9

Upstream product

• 3770-50-1 2-carbethoxyindole 
• 103-63-9 1-phenyl-2-bromoethane 
• 1973-22-4 1-bromo-2-ethylbenzene 

Downstream Products

• 108797-66-6 1-Phenethyl-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester 
• 108797-03-1 2-(4,5-Dihydro-1H-imidazol-2-yl)-1-phenethyl-2,3-dihydro-1H-indole 

Relevant academic research and scientific papers

Thiazolidinedione derivatives, method for preparing the derivatives and pharmaceutical compositions containing same

A thiazolidinedione derivative represented by the following general formula (I): STR1 ?wherein the dotted line represents a single bond or a double bond, the thiazolidinedione ring residue is linked to either of 2-, 3-, 4-, 5- and 6-positions on the indole ring and R represents a group selected from the group consisting of hydrogen atom and alkyl, alkenyl, alkynyl, phenyl, aralkyl, heterocycloalkyl, arylsulfonyl and arylaminocarbonyl groups! or a pharmaceutically acceptable salt thereof exhibits excellent effects of reducing the blood sugar level and of reducing the lipid concentration in blood and is accordingly useful as a therapeutic agent for treating diabates mellitus. These derivatives and pharmaceutically acceptable salt thereof are almost free of any side effect.

Microwave-assisted alkylations of activated methylene groups

Alkylations under 'dry conditions' of nitrophenylacetates, of an indole, and of methyl benzylidene glycinate induced by microwaves have been studied, leading to a very simple synthesis of arenes linked by a long hydrocarbon chain. N-Alkylation of the indole occurs, and monoalkylated methyl benzylideneglycinate is obtained, but in poor yield.