108805-08-9Relevant academic research and scientific papers
Carbophilic Additions of Organocuprates and 1,3-Thiazole-5(4H)-thiones
Jenny, Christjohannes,Wipf, Peter,Heimgartner, Heinz
, p. 1837 - 1843 (1986)
Organocuprates and 1,3-thiazole-5(4H)-thiones 1 react in THF at o deg via carbophilic addition onto the C=S bond to give 4,5-dihydro-1,3-thiazole-5-thiols 3 (Scheme 3).This observation is in marked contrast to the previously described reaction of organoli
Lithium diisopropylamide (LDA) as an efficient reducing agent for thioketones - Mechanistic consideration
Jasiński, Marcin,Mlostoń, Grzegorz,Gebert, Andreas,Heimgartner, Heinz
, p. 1281 - 1284 (2015/08/18)
Treatment of thiocarbonyl compounds with excess of lithium diisopropylamide (LDA) leads to corresponding thiols or sulfides depending on the work-up procedure. The mechanistic scenario for this unusual reduction pathway is discussed.
Reduction of thiocarbonyl compounds with lithium diisopropylamide
Gebert, Andreas,Jasiński, Marcin,Mlostoń, Grzegorz,Heimgartner, Heinz
, p. 931 - 938 (2014/08/05)
Treatment of 4,4-disubstituted 2-phenyl-1,3-thiazole-5(4H)-thiones with lithium diisopropylamide (LDA; LiNiPr2) in THF at -78° yielded the corresponding 1,3-thiazole-5(4H)-thioles in moderate yields. Sequential treatment with LDA and
