108840-84-2Relevant academic research and scientific papers
Nitromethane as a surrogate cyanating agent: 7-: N, N-dimethylamino-4-hydroxycoumarin-catalyzed, metal-free synthesis of α-iminonitriles
Satyanarayana, Iddum,Manjappa, Kiran B.,Yang, Ding-Yah
, p. 8316 - 8322 (2020)
An efficient, metal/alkali-cyanide free approach for the synthesis of α-iminonitriles via kinetically controlled, base-mediated and 1,3-diketone-catalyzed reaction is reported. The preparation of target compounds was realized by condensation of substituted anilines and aldehydes in nitromethane as a surrogate cyanating agent and as a solvent. This strategy was further improved by replacing aldehydes and nitromethane with β-nitrostyrene and ethanol, respectively, rendering the methodology greener. The catalytic role played by 1,3-diketones such as 7-N,N-dimethylamino-4-hydroxycoumarin in this three-component reaction was investigated, and a plausible mechanism was proposed based on control experiments.
