1088435-28-2Relevant academic research and scientific papers
Intramolecular ene reaction of a chiral bicyclic lactam
Resek, James E.
experimental part, p. 9792 - 9794 (2009/04/07)
(Chemical Equation Presented) The preparation of bicylic lactam 2 is described, employing an acetoacetate-based synthesis of 1,4-ketoacid 3. The lactam 2 was shown to undergo a thermal ene reaction at 280-300°C to afford tricycle 7. Reduction of the ene product followed by removal of the chiral auxiliary fragment provided the unusual lactam system 9 in highly enantioenriched form.
