108865-79-8Relevant academic research and scientific papers
Synthetic Access to All Four Stereoisomers of Oxetin
Kassir, Ahmad F.,Ragab, Sherif S.,Nguyen, Thao A. M.,Charnay-Pouget, Florence,Guillot, Régis,Scherrmann, Marie-Christine,Boddaert, Thomas,Aitken, David J.
, p. 9983 - 9991 (2016)
A short synthesis of all four stereoisomers of 3-amino-2-oxetanecarboxylic acid (oxetin) is described. The oxetane core is built using a Paternò-Büchi photochemical [2 + 2] cycloaddition; from the key intermediates, complementary resolution protocols provide access to enantiomerically pure oxetin and epi-oxetin on gram-scale.
