108867-86-3

Upstream product

• 5872-73-1 (2RS,3SR)-2-acetylamino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid ethyl ester 
• 100610-62-6 (2RS,3SR)-3-acetoxy-2-amino-3-phenyl-propionic acid ethyl ester; hydrochloride 
• 108-24-7 acetic anhydride 
• 19185-86-5 methyl (+/-)-erythro-N-acetyl-p-nitrophenylserinate 
• 19185-86-5 (+/-)-erythro-methyl-p-nitrophenylserinate 
• 5872-73-1 (+/-)-erythro-ethyl-p-nitrophenyl serinate 
• 69-96-5 dl-threo-phenylserine 
• 46506-67-6 (2RS,3SR)-2-acetylamino-3-hydroxy-3-phenyl-propionic acid 

Downstream Products

• 5872-73-1 (2S,3R)-2-acetylamino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid ethyl ester 
• 5872-74-2 (2RS,3SR)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid 
• 124339-65-7 (2R,3S)-2-acetylamino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid 
• 122675-07-4 (2S,3R)-threo-N-acetyl-p-nitrophenylserine 

Relevant academic research and scientific papers

Resolution of β-hydroxy-α-amino acids by the action of proteases on their N-acyl methyl esters

Methyl N-acetyl phenylserinates (1, 2), methyl N-acetyl nitrophenylserinates (3, 4), and methyl N-benzoyl threoninates (5, 6) were resolved conveniently into the enantiomers with high optical purities by enzymatic hydrolysis in the presence of α-chymotryp

Enzymatic Resolution of N-Acetyl p-Nitrophenylserinates

Asymmetric hydrolysis of alkyl (methyl and ethyl) (+/-)-erythro-p-nitrophenylserinates by α-chymotrypsin afforded optically active esters in optical purities above 95percent, but alkyl (+/-)-threo-p-nitrophenylserinates were not hydrolyzed.