108874-81-3Relevant academic research and scientific papers
Synthesis of functionalized 4-phenyl-pyridines via electrochemically prepared organozinc reagents
Gall, Erwan Le,Gosmini, Corinne,Nédélec, Jean-Yves,Périchon, Jacques
, p. 1923 - 1927 (2001)
The efficient and convenient synthesis of various functionalized 4-phenyl-pyridines 2 is described. The key step of the procedure is the electrochemical formation of aromatic organozinc reagents 1 and their coupling with pyridinium salts. Intermediate 1,4
C-F activation for C(sp2)-C(sp3) cross-coupling by a secondary phosphine oxide (SPO)-nickel complex
Müller, Valentin,Ghorai, Debasish,Capdevila, Lorena,Messinis, Antonis M.,Ribas, Xavi,Ackermann, Lutz
supporting information, p. 7034 - 7040 (2020/09/15)
A secondary phosphine oxide (SPO)-nickel catalyst allowed the activation of otherwise inert C-F bonds of unactivated arenes in terms of challenging couplings with primary and secondary alkyl Grignard reagents. The C-F activation is characterized by mild reaction conditions and high levels of branched selectivity. Electron-rich and electron-deficient arenes were suitable electrophiles for this transformation. In addition, this strategy also proved suitable to heterocycles and for the activation of C-O bonds under slightly modified conditions.
COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE
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Page/Page column 99, (2008/06/13)
The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
