108878-62-2Relevant articles and documents
Allicin and derivates are cysteine protease inhibitors with antiparasitic activity
Waag, Thilo,Gelhaus, Christoph,Rath, Jennifer,Stich, August,Leippe, Matthias,Schirmeister, Tanja
supporting information; experimental part, p. 5541 - 5543 (2010/12/25)
Allicin and derivatives thereof inhibit the CAC1 cysteine proteases falcipain 2, rhodesain, cathepsin B and L in the low micromolar range. The structure-activity relationship revealed that only derivatives with primary carbon atom in vicinity to the thiosulfinate sulfur atom attacked by the active-site Cys residue are active against the target enzymes. Some compounds also show potent antiparasitic activity against Plasmodium falciparum and Trypanosoma brucei brucei.
