108883-90-5

Basic information

• Product Name: 2-methoxy-4-[5-nitro-1H-benzo[d] imidazol-2-yl]phenol
• Synonyms: 2-methoxy-4-[5-nitro-1H-benzo[d] imidazol-2-yl]phenol
• CAS NO: 108883-90-5
• Molecular Weight: 285.259
• Mol File: 108883-90-5.mol

Chemical Properties

• CAS DataBase Reference: 2-methoxy-4-[5-nitro-1H-benzo[d] imidazol-2-yl]phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-4-[5-nitro-1H-benzo[d] imidazol-2-yl]phenol(108883-90-5)
• EPA Substance Registry System: 2-methoxy-4-[5-nitro-1H-benzo[d] imidazol-2-yl]phenol(108883-90-5)

Safety Data

• Hazardous Substances Data: 108883-90-5(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 99-56-9 4-Nitrophenylene-1,2-diamine 

Relevant articles and documents

Synthesis, characterization, and antimicrobial activity of new bis-1,2,3-triazol-H-yl-substituted 2-arylbenzimidazoles

New bis-1,2,3-triazol-H-yl-substituted 2-aryl benzimidazoles VIa-VIp were synthesized from O- and N-bis-propargyl substituted 2-arylbenzimidazoles using "click chemistry." The newly synthesized compounds were characterized by IR, NMR, and mass spectra. Th

A novel ternary GO@SiO2-HPW nanocomposite as an efficient heterogeneous catalyst for the synthesis of benzazoles in aqueous media

A new solid acid catalyst, consisting of 12-phosphotungstic heteropoly acid (HPW) supported on graphene oxide/silica nanocomposite (GO@SiO2), has been developed via immobilizing HPW onto an amine-functionalized GO/SiO2 surface through coordination interaction (GO@SiO2-HPW). The GO@SiO2-HPW nanocomposite was characterized by Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and powder X-ray diffraction (XRD). The prepared nanocomposite could be dispersed homogeneously in water and further used as a heterogeneous, reusable, and efficient catalyst for the synthesis of benzimidazoles and benzothiazoles by the reaction of 1,2-phenelynediamine or 2-aminothiophenol with different aldehydes.

NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR

Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

Synthesis, vasorelaxant activity and antihypertensive effect of benzo[d]imidazole derivatives

A series of 1H-benzo[d]imidazole analogues of Pimobendan, substituted at position 5 with either -CF3 or -NO2, were synthesized using a short synthetic route. All the nitro derivatives were potent, and exhibited a concentration- and partial endothelium-dependent vasorelaxant effects, with EC50s 50 value of 1.81 μM and Emax of 91.7% for ex vivo relaxant response in intact aortic rings, resulting in a 2.5-fold higher activity compared to Pimobendan. The closely related 5-CF3 analogue (compound 8), was 19 times less potent than 13. The antihypertensive activity of compound 13 was evaluated at doses of 25, 50 and 100 mg kg-1, using spontaneously hypertensive rats (SHR), showing a statistically significant dose-dependent effect.