1088993-98-9

Basic information

• Product Name: [(3R,6R)-6-Methylpiperidin-3-yl]Methanol hcl
• Synonyms: [(3R,6R)-6-Methylpiperidin-3-yl]Methanol hcl;VTNSDDLUAVIRTL-ZJLYAJKPSA-N
• CAS NO: 1088993-98-9
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 165.66104
• EINECS: -0
• Mol File: 1088993-98-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [(3R,6R)-6-Methylpiperidin-3-yl]Methanol hcl(CAS DataBase Reference)
• NIST Chemistry Reference: [(3R,6R)-6-Methylpiperidin-3-yl]Methanol hcl(1088993-98-9)
• EPA Substance Registry System: [(3R,6R)-6-Methylpiperidin-3-yl]Methanol hcl(1088993-98-9)

Safety Data

• Hazardous Substances Data: 1088993-98-9(Hazardous Substances Data)

Usage

General Description

[(3R,6R)-6-Methylpiperidin-3-yl]Methanol HCl is a chemical compound that is a salt form of 6-methylpiperidine, which is a piperidine derivative. It is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The HCl form of this compound makes it more stable and easier to handle in laboratory settings. This chemical is used in various chemical reactions as a reagent and can also be used in medicinal chemistry for the synthesis of therapeutic drugs. It is important to handle this compound with care, as it can be hazardous if not used properly.

Upstream product

• 1088994-03-9 (6R)-methyl-6-methyl-2-oxopiperidine-3-carboxylate 
• 59104-44-8 2-(3-oxo-butyl)malonic acid dimethyl ester 
• 278789-37-0 (6-methyl-piperidin-3-yl)methanol 
• 1088994-05-1 (6R)-3-hydroxymethyl-6-methylpiperidin-2-one 
• 1088993-89-8 (2R,5R)-benzyl 5-(hydroxymethyl)-2-methyl-piperidine-1-carboxylate 

Downstream Products

• 1088994-00-6 (2-(2H-1.2.3-triazol-2-yl)phenyl )((2R,5R)-5-(hydroxymethyl)-2-methylpiperidin-1-yl)methanone 
• 1088991-72-3 2-methyl-6-(((3R,6R)-6-methyl-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-3-yl)methoxy)pyridine 
• 1222456-90-7 {(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methanol 

Relevant articles and documents

Convergent kilogram-scale synthesis of dual orexin receptor antagonist

MK-6096 is an orexin receptor antagonist in clinical trials for the treatment of insomnia. Herein we describe its first kilogram-scale synthesis. Chirality on the α-methylpiperidine core was introduced in a biocatalytic transamination using a three-enzyme system with excellent enantioselectivity (>99% ee). Low diastereoselectivity of the lactam reduction was overcome by development of a camphor sulfonic acid salt formation and dr upgrade. A chemoselective O-alkylation with 5-fluoro-2-hydroxypyridine was optimized and developed. Overall, 1.2 kg of MK-6069 was prepared in nine steps and 13% overall yield.

PROCESS FOR THE PREPARATION OF AN OREXIN RECEPTOR ANTAGONIST

The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.