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1089051-56-8

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1089051-56-8 Usage

Description

trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; ; EC50 = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, <10, 25, 3.3, and 5 μM, respectively) in vitro and/or ex vivo. It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.

Uses

Resveratrol-d4 is labelled Resveratrol (R150000) which is a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.

Check Digit Verification of cas no

The CAS Registry Mumber 1089051-56-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,9,0,5 and 1 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1089051-56:
(9*1)+(8*0)+(7*8)+(6*9)+(5*0)+(4*5)+(3*1)+(2*5)+(1*6)=158
158 % 10 = 8
So 1089051-56-8 is a valid CAS Registry Number.

1089051-56-8Upstream product

1089051-56-8Downstream Products

1089051-56-8Relevant articles and documents

trans-resveratrol-d4, a molecular tracer of the wild-type phytoalexin; synthesis and spectroscopic properties

Gabriele, Bartolo,Benabdelkamel, Hicham,Plastina, Pierluigi,Fazio, Alessia,Sindona, Giovanni,Di Donna, Leonardo

, p. 2953 - 2956 (2008)

A convenient, six-step synthesis of the so far unknown trans-resveratrol- d4, (E)-3′,4,5′-trihydroxy-2,3,5,6-tetradeuterostilbene, starting from commercially available phenol-d6, with an overall yield of 25%, is described. The final

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