108906-72-5Relevant academic research and scientific papers
Anti-HIV and NO production inhibition activities of epi-aleuritolic acid derivatives
Liu, Jia-Bao,Zhang, Ying,Cui, Bao-Song,Cao, Ying-Li,Yuan, Shao-Peng,Guo, Ying,Hou, Qi,Li, Shuai
, p. 515 - 524 (2013)
Fifteen epi-aleuritolic acid derivatives were synthesized and evaluated for anti-HIV activity in 293 T cells and NO production inhibition activity. Of the derivatives, 1, 2, 3, 4, 11, and 13 showed relatively potent anti-HIV activity with EC50 values ranging from 5.80 to 13.30 μM. The most potent compound, 3α-2′,2′-dimethylsuccinic acyl epialeuritolic acid (11), displayed significant anti-HIV activity with an EC50 value of 5.80 μM. Compounds 1, 3, 4, and 11 showed NO inhibition activity, with IC50 values ranging from 3.40 to 7.10 μM and compound 1 inhibited NO production with an IC50 value of 3.40 μM.
ENT-KAURENES AND OLEANANES FROM CROTON LACCIFERUS
Bandara, Ratnayake B.M.,Wimalasiri, W.R.,MacLeod, John K.
, p. 869 - 872 (1988)
Key Word Index-Croton lacciferus; Euphorbiaceae; ent-kauranes; oleananes; insecticidal activity.The roots of Croton lacciferus furnished three ent-kauranoids, two of which are new natural products, and two oleananes.Two of the kauranoids showed moderate insecticidal activity against Aphis craccivora.
Unambiguous structural and nuclear magnetic resonance spectral characterization of two triterpenoids of Maprounea guianensis by two-dimensional nuclear magnetic resonance spectroscopy
McLean, Stewart,Perpick-Dumont, Marion,Reynolds, William F.,Jacobs, Helen,Lachmansing, Sagar Singh
, p. 2519 - 2525 (2007/10/02)
It is shown that 1H-13C shift-correlated two-dimensional spectra obtained for polarization transfer via two bond and three-bond 13C-1H coupling can, in conjunction with related experiments, be used to assign unambiguously the molecular skelatons of two of the less common triterpenes, moretenone and 3-acetylaleuritolic acid.It is concluded that this is a technique of considerable generality for assigning structures of triterpenes and is more reliable than alternative approaches such as mass spectral fragmentation patterns.It has the additional benefit of simultaneously providing reliable 13C and 1H spectral assignments for these compounds.
