108915-03-3

Usage

Uses

Used in Asymmetric Catalysis:
(4S)-4-<(S)-1-Methylpropyl>-2-(2-pyridinyl)-2-oxazolin is utilized as a ligand in asymmetric catalysis, a process that is crucial for the production of enantiomerically pure compounds. Its chiral nature and stable coordination with transition metal ions make it an effective catalyst in creating chiral molecules, which are essential in the pharmaceutical industry for the development of drugs with specific biological activities.
Used in Pharmaceutical Synthesis:
As a building block, (4S)-4-<(S)-1-Methylpropyl>-2-(2-pyridinyl)-2-oxazolin is employed in the synthesis of various pharmaceuticals and organic compounds. Its unique structure and properties allow for the creation of novel molecules with potential therapeutic applications, contributing to the advancement of drug discovery and development.
Used in Chemical Research:
(4S)-4-<(S)-1-Methylpropyl>-2-(2-pyridinyl)-2-oxazolin is also used in chemical research for the study of coordination chemistry and the development of new materials. Its interaction with transition metal ions can lead to the discovery of new complexes with potential applications in areas such as catalysis, materials science, and sensors.

Upstream product

• 100-70-9 2-Cyanopyridine 
• 24629-25-2 (S)-isoleucinol 
• 19547-38-7 methyl pyridine-2-imidate 

Relevant academic research and scientific papers

Synthesis of Optically Active Bis(2-oxazolines): Crystal Structure of a 1,2-Bis(2-oxazolinyl)benzene * ZnCl2 Complex

Dinitriles (5-7, 12, 13) react with enantiomerically pure β-amino alcohols (8-11, 17) under zinc chloride catalysis to give optically active C2-symmetric bis(oxazolines). 1,2-Bis(2-oxazolin-2-yl)benzenes 1a-e are obtained under mild reaction conditions. 1H-NMR spectroscopy indicates the formation of 1:1 complexes 23 of these compounds with ZnCl2.The energy required for a conformational interconversion of zinc dichloride complex 23e was determined by variable-temperature 1H-NMR studies.An X-ray structure analysis was performed with the substituted zinc dichloride complex 23a.

Asymmetric Catalysis, 45. - Enantioselective Hydrosilylation of Ketones with 2/Pyridinyloxazoline Catalysts

21 optically active 2-(2-pyridinyl)oxazolines are synthesized from 2-cyanopyridine and optically pure amino alcohols.The new pyridinyloxazolines are used as cocatalysts together with 2 as homogeneous in situ catalysts in the enantioselective hydrosilylation of prochiral ketones with diphenylsilane.After hydrolysis, 1-phenylethanol is produced in 83.4percent ee from acetophenone.Another three ketones are included into these investigations.The optical purity depends on the rhodium/ligand, rhodium/ketone, and ketone/silane ratio as well as on the solvent.Compared with other organic solvents, hydrosilylations in the solvent CCl4 without exceptions result in better chemical yields and optical purities as consequence of a change in the catalytically active species due to oxidative addition of CCl4. - Keywords: Enantioselective hydrosilylation/ Optically active secondary alcohols/ Rhodium/ pyridinyloxazoline catalysts