1089180-29-9Relevant academic research and scientific papers
HIV PROTEASE INHIBITORS AND METHODS FOR USING
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Page/Page column 32, (2011/06/10)
Compounds that inhibit proteolytic enzymes of Human Immunodeficiency Virus (HIV) are described. Preparation of the inhibitors, pharmaceutical compositions containing them, and uses of the compounds or compositions for the treatment of HIV infections are also described.
Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: Structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies
Ghosh, Arun K.,Gemma, Sandra,Takayama, Jun,Baldridge, Abigail,Leshchenko-Yashchuk, Sofiya,Miller, Heather B.,Wang, Yuan-Fang,Kovalevsky, Andrey Y.,Koh, Yashiro,Weber, Irene T.,Mitsuya, Hiroaki
experimental part, p. 3703 - 3713 (2009/02/05)
Recently, we designed a series of novel HIV-1 protease inhibitors incorporating a stereochemically defined bicyclic fused cyclopentyl (Cp-THF) urethane as the high affinity P2-ligand. Inhibitor 1 with this P2-ligand has shown very impressive potency again
