1089192-63-1

Basic information

• Product Name: (S)-2-((Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoylamino)-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester
• Synonyms: (S)-2-((Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoylamino)-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester
• CAS NO: 1089192-63-1
• Molecular Weight: 967.314
• Mol File: 1089192-63-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-((Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoylamino)-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoylamino)-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester(1089192-63-1)
• EPA Substance Registry System: (S)-2-((Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoylamino)-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester(1089192-63-1)

Safety Data

• Hazardous Substances Data: 1089192-63-1(Hazardous Substances Data)

Upstream product

• 84624-17-9 N-(9-fluorenylmethoxycarbonyl)-D-valine 

Relevant articles and documents

Macrolactamization versus macrolactonization: Total synthesis of FK228, the depsipeptide histone deacetylase inhibitor

(Chemical Equation Presented) The cyclic depsipeptide FK228 is the only natural product histone deacetylase (HDAC) inhibitor that has advanced to clinical trials as an anticancer agent. While currently obtained by fermentation, total synthesis is an attractive alternative that will facilitate the preparation of unnatural analogues. The previous total syntheses of FK228 featured macrocylization by ester bond formation from a seco-hydroxy acid. Such routes are operationally jeopardized by the steric hindrance of the carboxylic acid and the sensitivity of the allylic alcohol toward elimination. We report a strategically different approach whereby the ester bond is formed intermolecularly at an early stage and macrocyclization is efficiently achieved by amide bond formation.