1089278-81-8Relevant articles and documents
2-pyridine substituted urea structural small molecule compounds as well as synthesis and application thereof
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Paragraph 0197; 0286-0288, (2020/03/03)
The invention relates to 2-pyridine substituted urea structural small molecule compounds as well as synthesis and application thereof. Specifically, the invention discloses the compounds represented by a formula (I) shown in the specification, enantiomers, diastereomers, racemates or a mixture of the compounds, or a pharmaceutically acceptable salt, hydrate and solvate of the compounds, a preparation method of the above materials, and applications of the above materials in preparation of an ASK1 small molecule inhibitor, or medicines for preventing and/or treating diseases related to ASK1, especially liver diseases, lung diseases, cardiovascular diseases, kidney diseases and metabolic diseases.
THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE
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Page/Page column 223, (2012/02/02)
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.