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1089281-75-3

4-(3-ethoxy-4-nitrophenyl)pyridine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1089281-75-3 Structure

  • Basic information

    1. Product Name: 4-(3-ethoxy-4-nitrophenyl)pyridine
    2. Synonyms: 4-(3-ethoxy-4-nitrophenyl)pyridine
    3. CAS NO:1089281-75-3
    4. Molecular Formula:
    5. Molecular Weight: 244.25
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1089281-75-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(3-ethoxy-4-nitrophenyl)pyridine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(3-ethoxy-4-nitrophenyl)pyridine(1089281-75-3)
    11. EPA Substance Registry System: 4-(3-ethoxy-4-nitrophenyl)pyridine(1089281-75-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1089281-75-3(Hazardous Substances Data)

1089281-75-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1089281-75-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,9,2,8 and 1 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1089281-75:
(9*1)+(8*0)+(7*8)+(6*9)+(5*2)+(4*8)+(3*1)+(2*7)+(1*5)=183
183 % 10 = 3
So 1089281-75-3 is a valid CAS Registry Number.

1089281-75-3Downstream Products

1089281-75-3Relevant articles and documents

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity

Watts, Ellen,Heidenreich, David,Tucker, Elizabeth,Raab, Monika,Strebhardt, Klaus,Chesler, Louis,Knapp, Stefan,Bellenie, Benjamin,Hoelder, Swen

, p. 2618 - 2637 (2019/03/07)

Concomitant inhibition of anaplastic lymphoma kinase (ALK) and bromodomain-4 (BRD4) is a potential therapeutic strategy for targeting two key oncogenic drivers that co-segregate in a significant fraction of high-risk neuroblastoma patients, mutation of ALK and amplification of MYCN. Starting from known dual polo-like kinase (PLK)-1-BRD4 inhibitor BI-2536, we employed structure-based design to redesign this series toward compounds with a dual ALK-BRD4 profile. These efforts led to compound (R)-2-((2-ethoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-7-ethyl-5-methyl-8-((4-methylthiophen-2-yl)methyl)-7,8-dihydropteridin-6(5H)-one (16k) demonstrating improved ALK activity and significantly reduced PLK-1 activity, while maintaining BRD4 activity and overall kinome selectivity. We demonstrate the compounds' on-target engagement with ALK and BRD4 in cells as well as favorable broad kinase and bromodomain selectivity.

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