108930-58-1Relevant articles and documents
Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4- dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage
Kappe, C. Oliver
, p. 49 - 51 (2007/10/03)
A series of pharmacologically active, functionalized 4-aryl-3,4- dihydropyrimidine-5-carboxylates (DHPMs) are prepared by a versatile novel solid phase approach. In the key step, a polymer-bound thiouronium salt is condensed with unsaturated β-ketoesters. The resulting polymer bound 1,4- dihydropyrimidines are cleaved from the resin employing multidirectional resin cleavage strategies.
Substituted 1,4-dihydropyrimidines. 3.1 Synthesis of selectively functionalized 2-hetero-1,4-dihydropyrimidines
Atwal,Rovnyak,O'Reilly,Schwartz
, p. 5898 - 5907 (2007/10/02)
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