108932-12-3Relevant academic research and scientific papers
2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters
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, (2008/06/13)
Pyrimidine compounds of the formula STR1 wherein X is sulfur or oxygen, Y is R11 or --O--R1, and R4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents, particularly anti-hypertensive
Dihydropyrimidine Calcium Channel Blockers. 4. Basic 3-Substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic Acid Esters. Potent Antihypertensive Agents
Rovnyak, George C.,Atwal, Karnail S.,Hedberg, Anders,Kimball, David S.,Moreland, Suzanne,et al.
, p. 3254 - 3263 (2007/10/02)
We have examined a series of novel dihydropyrimidine calcium channel blockers that contain a basic group attached to either C5 or N3 of the heterocyclic ring.Structure-activity studies show that a 1-(phenylmethyl)-4-piperidinyl carbamate moiety at N3 and
