1089338-38-4Relevant academic research and scientific papers
Synthesis of Benzannulated [6,6]-Spiroketals by a One-Pot Carbonylative Sonogashira Coupling/Double Annulation Reaction
Xiang, Kuirong,Tong, Pei,Yan, Baorun,Long, Lingling,Zhao, Chunbo,Zhang, Yuan,Li, Ying
, p. 412 - 416 (2019/01/23)
A one-pot Pd-catalyzed carbonylative Sonogashira coupling in tandem with double annulation reaction to synthesize benzannulated [6,6]-spiroketals from o-iodophenols and terminal alkynols or alkynyl phenols was achieved. The protocol provides straightforwa
Synthesis of 6,6-bisbenzannulated spiroketals related to the rubromycins using a double intramolecular hetero-Michael addition (DIHMA)
Choi, Peter J.,Rathwell, Dominea C.K.,Brimble, Margaret A.
scheme or table, p. 3245 - 3248 (2009/08/17)
The synthesis of a series of 6,6-bisbenzannulated spiroketals using a novel microwave-assisted DIHMA approach is reported. Coupling of an aryl acetylene and an aryl aldehyde via acetylide anion addition resulted in the formation of an alkynol which was followed by oxidation to the desired ynone. Spirocyclization using the DIHMA protocol afforded the desired bisbenzannulated spiroketal in good yield.
