108966-71-8

Basic information

• Product Name: 3,4-DIFLUOROBENZENESULFONAMIDE
• Synonyms: 3,4-DIFLUOROBENZENESULFONAMIDE;3,4-DIFLUOROBENZENESULPHONAMIDE;BUTTPARK 21\07-17;Benzenesulfonamide, 3,4-difluoro- (9CI)
• CAS NO: 108966-71-8
• Molecular Formula: C₆H₅F₂NO₂S
• Molecular Weight: 193.17
• Product Categories: SULFONAMIDE;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds;Aryl Fluorinated Building Blocks;Building Blocks;C6;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Sulfur Compounds
• Mol File: 108966-71-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 89-93 °C(lit.)
• Boiling Point: 314.4 °C at 760 mmHg
• Flash Point: 143.9 °C
• Appearance: /
• Density: 1.523 g/cm³
• Vapor Pressure: 0.000468mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.79±0.60(Predicted)
• CAS DataBase Reference: 3,4-DIFLUOROBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIFLUOROBENZENESULFONAMIDE(108966-71-8)
• EPA Substance Registry System: 3,4-DIFLUOROBENZENESULFONAMIDE(108966-71-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 108966-71-8(Hazardous Substances Data)

Usage

General Description

3,4-Difluorobenzenesulfonamide is a chemical compound with the formula C6H5F2NO2S. It is a sulfonamide derivative, featuring a sulfonamide group and two fluorine atoms attached to a benzene ring. 3,4-DIFLUOROBENZENESULFONAMIDE is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable intermediate in organic chemistry, particularly in the development of new drugs and crop protection products. 3,4-Difluorobenzenesulfonamide has potential applications in the treatment of various diseases and as an active ingredient in pest control products.

InChI:InChI=1/C6H5F2NO2S/c7-5-2-1-4(3-6(5)8)12(9,10)11/h1-3H,(H2,9,10,11)

Upstream product

• 367-11-3 ortho-difluorobenzene 
• 145758-05-0 3,4-difluorobenzenesulfonyl chloride 

Downstream Products

• 252561-98-1 3-fluoro-4-hydrazino-1-benzenesulfonamide hydrochloride 
• 499152-80-6 N-(3,4-difluorophenylsulfonyl)-3-(2-(2-(naphthalen-2-yl)ethoxy)-4-(pyridin-3-yloxymethyl)phenyl)propanamide 
• 499152-67-9 N-(3,4-difluorophenylsulfonyl)-3-(2-(2-(naphthalen-2-yl)ethoxy)-4-(3-cyanophenoxymethyl)phenyl)propanamide 
• 499152-79-3 N-(3,4-difluorophenylsulfonyl)-3-(2-(2-(naphthalen-2-yl)ethoxy)-4-(morpholin-4-ylmethyl)phenyl)propanamide 
• 499153-22-9 N-(3,4-difluorophenylsulfonyl)-3-(2-(2-(naphthalen-2-yl)ethoxy)-4-dimethylaminomethylphenyl)propanamide 
• 499153-03-6 N-(3,4-difluorophenylsulfonyl)-3-(2-((naphthalen-1-ylmethyl)carbamoyl)-4-(pyrazol-1-ylmethyl)phenyl)propanamide 
• 499152-49-7 N-(3,4-difluorophenylsulfonyl)-3-(2-(2-(naphthalen-2-yl)ethoxy)-4-(pyrazol-1-ylmethyl)phenyl)propanamide 
• 883000-84-8 3,4-difluoro-N-[(E)-3-(5-fluoro-3-methyl-1H-indol-7-yl)acryloyl]benzenesulfonamide 
• 1057257-63-2 C₂₆H₁₈F₂N₄O₄S 

Relevant articles and documents

1- [4- (SULFONYL) -PHENYL] -5- (BENZYL) -IH-I, 2, 4-TRIAZOL DERIVATIVES AS INHIBITORS OF CARBONIC ANHYDRASE FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION

The invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4 and RA through RE are as defined herein. The invention also relates to methods of treating glaucoma, ocular hypertension, age-related macular degeneration, diabetic macular edema, diabetic retinopathy, hypertensive retinopathy, retinal vasculopathies and intraocular pressure in mammals by administering the compounds of formula I, and to pharmaceutical compositions which contain the compounds of formula I for such treatments. The invention also relates to methods of preparing the compounds of formula (I).

Topically active carbonic anhydrase inhibitors. 4. [(hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides

For several decades a tantalizing goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase inhibitor. Recent results from several research groups indicate that considerable progress has been made toward this objective. In this report, we present the design and synthesis of (hydroxyalkyl)sulfonyl-substituted benzene- and thiophenesulfonamides. These compounds exhibit inhibition of carbonic anhydrase II in the nanomolar range and lower intraocular pressure in the α-chymotrypsinized rabbit model of ocular hypertension after topical instillation.