1089671-28-2Relevant academic research and scientific papers
Synthesis and sedative activity of 5-(4'-β-D-allopyranosyloxyphenyl)- 3-aryl- 4,5-dihydropyrazole-1-carbothioamides
Fu, Li,Ye, Ding,Peng Chen, Guo,Li, Ying,Fan Yin, Shu
, p. 417 - 420 (2010)
5-(4'-β-D-Allopyranosyloxyphenyl)-3-aryl-4,5-dihydropyrazole-1- carbothioamides (2a-2h) were synthesized by the reaction of (1a-1h) with thiosemicarbazide and KOH in ethanol. The structures of all new compounds were characterized by 1HNMR, IR, and MS (HR-MS) spectra. A preliminary bioassay test of 1f-1h and 2a-2h suggested that most of these helicid analogues showed mild to strong activity. Compounds 1g, 2a, 2c, and 2f at a dose of 200 mg?kg-1 were better than that of the parent helicid.
