1089672-70-7Relevant articles and documents
5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)
Winters, Michael P.,Robinson, Darius J.,Khine, Hnin Hnin,Pullen, Steven S.,Woska Jr., Joseph R.,Raymond, Ernest L.,Sellati, Rosemarie,Cywin, Charles L.,Snow, Roger J.,Kashem, Mohammed A.,Wolak, John P.,King, Josephine,Kaplita, Paul V.,Liu, Lisa H.,Farrell, Thomas M.,DesJarlais, Renee,Roth, Gregory P.,Takahashi, Hidenori,Moriarty, Kevin J.
scheme or table, p. 5541 - 5544 (2009/05/30)
A series of novel 5-aminomethyl-1H-benzimidazole based inhibitors of Itk were prepared. Structure-activity relationships, selectivity and cell activity are reported for this series. Compound 2, a potent and selective antagonist of Itk, inhibited anti-CD3 antibody induced IL-2 production in vivo in mice.
