108979-85-7Relevant academic research and scientific papers
Transition-metal-free multinitrogenation of amides by C-C bond cleavage: A new approach to tetrazoles
Li, Lian-Hua,Li, Ying-Xiu,Liang, Yong-Min,Niu, Zhi-Jie
supporting information, p. 11148 - 11151 (2020/04/22)
A metal-free brand-new one-pot multinitrogenation of amides for the chemo- A nd regioselective synthesis of 1,5-disubstituted tetrazoles has been developed. By means of electrophilic amide activation, and further C-C bond cleavage and rearrangement, a diverse set of functionalized 1,5-DST derivatives were selectively constructed under mild conditions. As showcased in the mechanisms, the chemoselectivity is easily switched by the selection of the starting materials in the reaction.
